Coach Nick Saban said Monday that Sunseri will have surgery on Tuesday. He declined to give specifics of the injury except that he had ligament damage.
Sunseri is the only defensive back to start each of the first seven games for the top-ranked Crimson Tide. He was injured while covering a kickoff in the first quarter against Arkansas.
Sunseri has 20 tackles and returned two interceptions for touchdowns.
The junior has played in 34 games and started 15 in his career.
Landon Collins is expected to replace him as the starter. Collins filled in at free safety during Ha Ha Clinton-Dix's two-game suspension that ended before the Arkansas game.